International Journal of Geriatric Psychiatry, 33(2), 379–388.Ĭhan, P., & Brew, B. A re-examination of Montreal cognitive assessment (MoCA) cutoff scores. Journal of the Neurological Sciences, 260(1–2), 11–15.Ĭarson, N., Leach, L., & Murphy, K. The HIV dementia scale: Predictive power in mild dementia and HAART. Applied Neuropsychology: Adult, 20(1), 33–40.īottiggi, K. Validity of the Montreal cognitive assessment in the detection of cognitive dysfunction in Huntington's disease. Updated research nosology for HIV-associated neurocognitive disorders. Accessed 12 January 2019.Īntinori, A., Arendt, G., Becker, J. BHIVA guidelines for the routine investigation and monitoring of adult HIV-1-positive individuals. Clinical Infectious Diseases, 58(1), e1–e34.Īngus, B., Awosusi, F., Barker, G., Boffito, M., Brook, G., Das, S., et al. Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV medicine Association of the Infectious Diseases Society of America. Nonetheless, the choice of cut-off always comes with a sensitivity-specificity trade-off, the preferred cut point depending on whether sensitivity or specificity is more valuable in a given context.Īberg, J. A lower threshold than the original cut-off of 26 is probably more useful for optimal screening of HAND, as it lowers false positive rates and improves diagnostic accuracy. The MoCA test provides information about general cognitive functioning disturbances that contribute to a diagnosis of HAND. The accuracy of MoCA for diagnosing HAND was reported at six cut-off points (scores 22–27). We assessed most studies as being applicable to the review question though we had concerns about the selection of participants in three studies. Recruitment period ranged from 2009 to 2015. Overall, 1014 patients were included but most studies recruited small samples. Eight cross-sectional studies met the inclusion criteria for meta-analysis. Quality assessment was performed according to the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) criteria. We extracted dichotomized positive and negative test results at various thresholds and calculated the sensitivity and specificity of MoCA. We conducted a systematic literature review, searching five databases from inception until January 2019. This study aims to systematically review the evidence on the accuracy of the Montreal Cognitive Assessment (MoCA) test for diagnosing HIV–associated neurocognitive disorders (HAND) and to outline the quality and quantity of research evidence available about the accuracy of MoCA in populations infected with HIV.
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